SRP5123
RAC3, His tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
biological source
human
recombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~24 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RAC3(5881)
General description
RAC3 is a GTPase which belongs to the RHO family of small GTP-binding proteins that regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. RAC3 is primarily expressed in brain and is proposed to play a specific function in neuronal cells. Depletion of RAC3 induces stronger cell adhesion and dramatically increases the outgrowth of neurite-like protrusions whereas overexpression of RAC3 results in a contractile round morphology. RAC3 can exert its function through negatively affecting integrin-mediated cell-matrix adhesions. RAC3 shares with RAC1 the ability to interfere with cadherin-mediated adhesion.
Physical form
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling.
Amra Hajdo-Milasinovic et al.
Journal of cell science, 122(Pt 12), 2127-2136 (2009-06-06)
Rac1 and Rac3 are highly homologous regulatory proteins that belong to the small GTPases of the Rho family. Previously, we showed that Rac3 induces cell rounding and prevents neuronal differentiation, in contrast to its close relative Rac1, which stimulates cell
Encarnación Lozano et al.
Journal of cell science, 121(Pt 7), 933-938 (2008-03-06)
E-cadherin cell-cell adhesion plays a major role in the maintenance of the morphology and function of epithelial tissues. Modulation of E-cadherin function is an important process in morphogenesis and tumour de-differentiation. We have previously shown that constitutively active Rac1 induces
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