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Merck
CN

SRP6005

Sigma-Aldrich

FGF-21 murine

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

FGF21, FGFL, Fibroblast growth factor 21

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About This Item

CAS Number:
288640-33-5
UNSPSC Code:
12352202
NACRES:
NA.32

Key Documents

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biological source

mouse

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

20.1 kDa

packaging

pkg of 10 μg

impurities

Endotoxin, tested

NCBI accession no.

Q9JJN1

UniProt accession no.

Q9JJN1

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... FGF-21(56636)

General description

Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal methionine and having a molecular mass of 20.1kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.The FGF-21 is purified by proprietary chromatographic techniques. FGF21 (fibroblast growth factor) is a hormonal factor that belongs to the FGF superfamily. It is generated by the liver. The gene encoding FGF21 is localized on mouse chromosome 7.

Biochem/physiol Actions

FGF21 (fibroblast growth factor) controls glucose homeostasis and energy metabolism. It exhibits anti-diabetic properties by controlling glucose uptake in peripheral tissues. FGF21 also possesses autocrine effects in white adipose tissue. The protein is also involved in bone loss and exhibits hepatoprotective properties. In addition, FGF21 is also implicated in lipid metabolism and energy balance. It plays a key role in controlling oxidative stress cell response.

Physical form

Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61267
70267

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A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wang X, et al.
Cell Metabolism (2015)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21.
The Journal of Biological Chemistry (2016)
Fibroblast growth factor 21 in breast milk controls neonatal intestine function.
Gavalda-Navarro A, et al.
Scientific Reports, 5 (2015)
Fibroblast growth factor 21 and its novel association with oxidative stress.
Gomez-S, et al.
Redox Biology (2017)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein.
PLoS ONE (2016)
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