SRP6031
BMPR1A human
recombinant, expressed in Insect cells (Baculovirus), ≥90% (SDS-PAGE), ≥90% (HPLC)
Synonym(s):
BMP-R1A, BMPR-1A, BMPR1A, BMR1A, CD292
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Biological source:
human
Recombinant:
expressed in Insect cells (Baculovirus)
Assay:
≥90% (HPLC), ≥90% (SDS-PAGE)
Form:
lyophilized
Mol wt:
23.0 kDa
Impurities:
Endotoxin, tested
biological source
human
recombinant
expressed in Insect cells (Baculovirus)
assay
≥90% (HPLC), ≥90% (SDS-PAGE)
form
lyophilized
mol wt
23.0 kDa
packaging
pkg of 10 μg
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BMPR1A(657)
General description
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the Activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.
Physical form
Lyophilized from sterile PBS.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Amy L Strong et al.
Stem cells and development, 30(2), 91-105 (2020-12-02)
Traumatic heterotopic ossification (tHO) commonly develops in wounded service members who sustain high-energy and blast-related traumatic amputations. Currently, no safe and effective preventive measures have been identified for this patient population. Bone morphogenetic protein (BMP) signaling blockade has previously been
Venetia Bigley et al.
Journal of leukocyte biology, 97(4), 627-634 (2014-12-18)
Langerin is a C-type lectin expressed at high level by LCs of the epidermis. Langerin is also expressed by CD8(+)/CD103(+) XCR1(+) cross-presenting DCs of mice but is not found on the homologous human CD141(high) XCR1(+) myeloid DC. Here, we show
Christine Bruun et al.
Diabetologia, 57(12), 2546-2554 (2014-09-28)
Impairment of beta cell mass and function is evident in both type 1 and type 2 diabetes. In healthy physiological conditions pancreatic beta cells adapt to the body's increasing insulin requirements by proliferation and improved function. We hypothesised that during
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP6031-10UG | 04061832783925 |