SRP6038
RBP4 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
Plasma retinol-binding protein, RBP, Retinol binding protein 4
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
biological source
human
recombinant
expressed in E. coli
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
liquid
mol wt
21.0 kDa
packaging
pkg of 20 μg
concentration
~1 mg/mL
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... RET4(5950)
General description
RBP4 (retinol binding protein 4) was originally recognized in 2005 as an adipocytokine. It is predominantly produced by hepatocytes and adipose tissues. This gene is localized to human chromosome 10q23–24 and is composed of five exons and six introns. RBP-4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 21 kDa. The Retinol Binding Protein-4 is purified by proprietary chromatographic techniques.
Biochem/physiol Actions
RBP4 (retinol binding protein 4) was initially identified as a cytokine capable of increased liver gluconeogenesis and decreasing insulin sensitivity. In subjects with obesity, impaired glucose tolerance, or type 2 diabetes and in non-obese, non-diabetic subjects with a strong family history of type 2 diabetes, the serum levels of this protein correlate to the degree of insulin resistance. This protein is thought to contribute to the pathogenesis of type 2 diabetes. Studies in obese mice show that fenretinide, a synthetic retinoid, increases the urinary excretion of RBP4, thus, normalizing serum RBP4 levels. This results in improved insulin resistance and glucose intolerance, suggesting that decreasing RBP4 levels might have potential as a therapeutic strategy for type 2 diabetes.
Physical form
Sterile filtered solution (1 mg/ml) in PBS, pH 7.4
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.
Hu S
BMC Pregnancy and Childbirth, 16, 52-52 (2016)
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.
Yang Q
Nature, 436, 356-362 (2005)
Jingjing Wang et al.
Atherosclerosis, 240(2), 335-344 (2015-04-16)
Mitochondrial dysfunction has been implicated in cardiovascular diseases. Elevation of serum retinol binding protein 4 (RBP4) in patients has been linked to cardiovascular disease. However, the role of RBP4 on mitochondrial oxidative stress and vascular oxidative damage is not well
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