SRP6040
TIMP-1 human
recombinant, expressed in Sf9 cells, ≥92% (SDS-PAGE)
Synonym(s):
TIMP, TIMP recombinant, TIMP-1 protein, Tissue Inhibitor of matrix metalloproteinases-1
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
≥92% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in Sf9 cells
Mol wt:
28.0 kDa
biological source
human
recombinant
expressed in Sf9 cells
assay
≥92% (SDS-PAGE)
form
liquid
mol wt
28.0 kDa
packaging
pkg of 5 μg
manufacturer/tradename
Croda International PLC
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−70°C
Gene Information
human ... TIMP1(7076)
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General description
TIMP1 (tissue inhibitor of metalloproteinase 1) is a glycoprotein and is a member of TIMP family of endogenous MMP (matrix metalloproteinase) inhibitors. Humans contain four TIMPs. All TIMPs contain an N-terminal of 125 residues, a 65-residue C-terminal, and both these domains contain three disulfide bonds. The N-terminal domain inhibits MMPs by folding into a separate unit. TIMP1 is encoded by the gene mapped to human chromosome Xp11.23.
Biochem/physiol Actions
TIMP1 functions as a poor inhibitor of MT1 (membrane type 1)-MMP, MT3-MMP, MT5-MMP and MMP-19. It inhibits ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) protein. In human umbilical vein endothelial cells (HUVECs), the down-regulation of TIMP1 and up-regulation of MMP-3 results in aberrant endothelium-dependent vasodilation, EC (endothelial cell) death, and endothelial interruption in a FOXO3 (forkhead box O3)-mediated manner. In patients with CAD (coronary artery disease) and acute coronary syndrome (ACS), the urine levels of this protein are elevated. This protein interacts with Bcl-2 (B cell lymphoma) protein, and induces apoptosis in lung adenocarcinoma cells. The plasma levels of this protein are increased in patients with obesity and obesity-related disorders, such as steatosis, where it participates in pathogenesis of diet-induced hepatic steatosis and glucose intolerance.
Physical form
In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl?; 1 ?M ZnCl?; 0.05% Brij® L23; 0,05% NaN?
Legal Information
Brij is a registered trademark of Croda International PLC
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Polymorphic X-chromosome inactivation of the human TIMP1 gene.
Anderson CL and Brown CJ
American Journal of Human Genetics, 65(3), 699-708 (1999)
Tissue Inhibitor Of Matrix Metalloproteinase-1 Is Required for High-Fat Diet-Induced Glucose Intolerance and Hepatic Steatosis in Mice.
Fj?re E, et al.
PLoS ONE, 10(7) (2015)
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.
Benjamin MM1 and Khalil RA.
EXS, 103, 209-279 (2012)
TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2.
Nalluri S, et al.
PLoS ONE, 10(9) (2015)
Lena Vinther et al.
Protein expression and purification, 101, 157-164 (2014-07-08)
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is an endogenous inhibitor of matrix metalloproteinases (MMPs) with reported tumor promoting, as well as inhibitory, effects. These paradoxical properties are presumably mediated by different biological functions, MMP-dependent as well as -independent, and probably related
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