SRP6051
RAGE human
recombinant, expressed in human cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
HDNF, NGF-2, NT-3, Neurotrophin-3, Receptor for advanced glycosylation end products
General description
Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Physical form
Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.
Preparation Note
Centrifuge the vial prior to opening.
Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.
Other Notes
Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly-histidine tag at the C-terminus.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Varun Kumar et al.
Nucleic acids research, 45(18), 10595-10613 (2017-10-05)
The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the spatio-mechanical processes of double-strand break (DSB)-repair, especially
Valerie R Wiersma et al.
Lung, 200(6), 687-690 (2022-10-26)
The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and progression of chronic obstructive pulmonary disease (COPD). However, cigarette smoking causes a nearly instant drop in circulating sRAGE
Zheng-Wen He et al.
Mediators of inflammation, 2013, 596716-596716 (2013-12-05)
Synovial fibroblasts (SF) play a central role in the inflammatory and destructive process in rheumatoid arthritis (RA). High-mobility group box chromosomal protein 1 (HMGB1) or lipopolysaccharide (LPS) alone failed to induce significant changes in proliferation of cultured SF from RA
Cherilyn M Sirois et al.
The Journal of experimental medicine, 210(11), 2447-2463 (2013-10-02)
Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage. Activation of immune signaling receptors by nucleic acids is controlled by limiting the access of DNA and
Ruo-Chan Chen et al.
Molecular and cellular biochemistry, 390(1-2), 271-280 (2014-02-11)
High mobility group protein box1 (HMGB1) and its receptor-receptor for advanced glycation end products (RAGE) are pivotal factors in the development and progression of many types of tumor, but the role of HMGB1-RAGE axis in hepatocellular carcinoma (HCC) especially its
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