SRP6164
G-CSF human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
CSF-3, Filgrastim, GM-CSF beta, MGI-1G, Pluripoietin
biological source
human
recombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
form
lyophilized
potency
0.02-0.08 ng/mL
mol wt
21-25 kDa (monomer, glycosylated)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CSF3(1440)
General description
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a cytokine. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the GCSF gene. Human and murine G-CSF is cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17.
Biochem/physiol Actions
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Granulocyte colony stimulating factor (G-CSF) controls the production, differentiation and function of granulocytes. It has been shown to have a role in bone repair in animal models. G-CSF has been clinically approved for neutropenia treatment.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Lian Cai et al.
PloS one, 15(3), e0230247-e0230247 (2020-03-18)
Granulocyte-colony stimulating factor (G-CSF), a pleiotropic cytokine, belongs to the hematopoietic growth factor family. Recent studies have reported that G-CSF is a predictive biomarker of oocyte and embryo developmental competence in humans. The aim of our study was to determine
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Kim JS
Oncology Reports, 34(1), 147-154 (2015)
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma.
Swift A
British Journal of Cancer, 71(5), 995-998 (1995)
Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts.
Liu XL
BioMed Research International, 8485721-8485721 (2016)
Akiko Sugiyama et al.
Chronobiology international, 32(7), 934-941 (2015-07-15)
Circulating hematopoietic stem cells exhibit robust circadian fluctuations, which influence the mobilized cell yield, even during enforced stem cell mobilization. However, alterations in the expression of circadian clock genes during granulocyte colony-stimulating factor (G-CSF)-induced peripheral blood stem cell (PBSC) mobilization
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