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Merck
CN

SRP6240

Sigma-Aldrich

TWEAK Receptor human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonym(s):

FGFinducible 14, TNF-related weak inducer of apoptosis receptor, TNFRSF12A, TWEAKR

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

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biological source

human

recombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

5.6 kDa

packaging

pkg of 10 μg
pkg of 50 μg

UniProt accession no.

Q9NP84

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TNFRSF12A(51330)

General description

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic “death domain,” which can activated the cell′s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein.

Physical form

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5 and 50 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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