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SRP6286

Sigma-Aldrich

PCSK9 murine

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

Synonym(s):

FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PCSK9, Proprotein convertase subtilisin/kexin type 9

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

Key Documents

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biological source

mouse

recombinant

expressed in HEK 293 cells

tag

6-His tagged (N-terminus)

Assay

≥97% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 72 kDa
observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .)
observed mol wt 64 kDa

packaging

pkg of 20 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

Q80W65

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... PCSK9(100102)

General description

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Physical form

Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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