Skip to Content
Merck
CN

SRP6286

PCSK9 murine

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

Synonym(s):

FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PCSK9, Proprotein convertase subtilisin/kexin type 9

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized powder
Assay:
≥97% (SDS-PAGE)
Biological source:
mouse
Recombinant:
expressed in HEK 293 cells
Mol wt:
calculated mol wt 72 kDa, observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .), observed mol wt 64 kDa

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

mouse

recombinant

expressed in HEK 293 cells

tag

6-His tagged (N-terminus)

assay

≥97% (SDS-PAGE)

form

lyophilized powder

mol wt

calculated mol wt 72 kDa, observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .), observed mol wt 64 kDa

packaging

pkg of 20 μg

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

Q80W65

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... PCSK9(100102)

General description

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Physical form

Sterile filtered through a 0.22 micron filter. Lyophilized from 1 x PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 100 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service