SRP6302
Apolipoprotein B from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Apo-B
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
550 kDa
biological source
human plasma
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
550 kDa
packaging
pkg of 500 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ApoB(338)
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General description
Apolipoprotein B is the dominant protein constituent of low-density lipoprotein (LDL). The concentration of Apo B in normal plasma is 90mg/100mL. Two forms of Apo B exist: Apo B-100 and Apo B-48. The first is found in VLDL and LDL and is produced by the liver. The second is found in chylomicrons and originates in the intestine. The gene encoding this protein is localized on chromosome 2p24.1.
Biochem/physiol Actions
Apo B is thought to stabilize lipid emulsions, serve as a cofactor and modulator of enzymatic reactions, manage export of lipids out of cells and direct lipids to target organs. Apo B levels are positively correlated with the risk of coronary disease. Apo B levels may be a more sensitive predictor of cardiovascular risk than LDL levels and do not involve fasting for accurate measurement. Mutations in this gene or its regulatory region cause hypoβ-lipoproteinemia, normotriglyceridemic and hypercholesterolemia due to ligand-defective ApoB, diseases affecting plasma cholesterol and ApoB levels.
Physical form
Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCI.
Preparation Note
In water or aqueous buffer
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Low-density lipoprotein cholesterol, apolipoprotein B, and risk of coronary heart disease: from familial hyperlipidemia to genomics.
Imes CC and Austin MA
Biological Research for Nursing, 15(3), 292-308 (2013)
Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins.
Chan L
The Journal of Biological Chemistry, 267(36), 25621-25624 (1992)
Mechanisms of disease: genetic causes of familial hypercholesterolemia.
Soutar AK and Naoumova RP
Nature Clinical Practice. Cardiovascular Medicine, 4(4), 214-225 (2007)
Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions.
Heijmans BT
European Journal of Human Genetics, 13(10), 1143-1153 (2005)
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