SRP6345
TNFSF8 human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym(s):
CD153, CD30L, CD30LG, tumor necrosis factor ligand superfamily member 8
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
≥80% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
22 kDa (195 aa, 63-234 aa + His Tag)
biological source
human
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
liquid
mol wt
22 kDa (195 aa, 63-234 aa + His Tag)
packaging
pkg of 50 μg
concentration
0.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TNFSF8(944)
General description
TNFSF8 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. TNFSF8 was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin′s and some non-Hodgkin′s lymphomas. Recombinant human TNFSF8 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Physical form
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol and 0.4 M Urea.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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