SRP6432
CD58/LFA-3 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(s):
Ag3
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
calculated mol wt 22.3 kDa, observed mol wt 30-45 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 29 is the predicted N-terminal.)
biological source
human
recombinant
expressed in HEK 293 cells
tag
6-His tagged (C-terminus)
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
calculated mol wt 22.3 kDa, observed mol wt 30-45 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 29 is the predicted N-terminal.)
packaging
pkg of 10 μg, pkg of 50 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CD58(965)
General description
Cluster of differentiation 58 (CD58), also known as lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on antigen presenting cells (APC), particularly macrophages. The gene encoding this protein is localized on human chromosome 1p13.1.
CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Biochem/physiol Actions
Cluster of differentiation 58 (CD58)/lymphocyte function-associated antigen 3 (LFA-3) is a ligand of the T-lymphocyte cluster of differentiation 2 (CD2) glycoprotein, which binds to CD2 (LFA-2) on T cells. It is important in strengthening the adhesion between the T cells and professional antigen presenting cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Physical form
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Raychaudhuri S, et al.
Nature Genetics, 41(12), 1313-1313 (2009)
Intracellular adhesion molecule-1 modulates β-chemokines and directly costimulates T cells in vivo.
Kim J J., et al.
The Journal of Clinical Investigation, 103(6), 869-877 (1999)
CD58 polymorphisms associated with the risk of neuromyelitis optica in a Korean population.
Kim J Y, et al.
BMC Neurology, 14(1), 57-57 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP6432-10UG | 04061837287916 |
| SRP6432-50UG | 04061837287923 |
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