SRP6469
VLDLR human
recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)
Synonym(s):
CARMQ1, CHRMQ1, FLJ35024, VLDL-R, VLDLRCH, very-low-density-lipoprotein receptor
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About This Item
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥97% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
calculated mol wt 86 kDa, observed mol wt 150 kDa by SDS-PAGE (DTT-reduced.), observed mol wt 180 kDa
biological source
human
recombinant
expressed in HEK 293 cells
tag
6-His tagged (C-terminus)
assay
≥97% (SDS-PAGE)
form
lyophilized
mol wt
calculated mol wt 86 kDa, observed mol wt 150 kDa by SDS-PAGE (DTT-reduced.), observed mol wt 180 kDa
packaging
pkg of 10 μg, pkg of 50 μg
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VLDLR(7436)
General description
Very-low-density-lipoprotein receptor (VLDLR) is a 130 kDa type I transmembrane protein in the low density lipoprotein (LDL) receptor family that plays a significant role in lipid metabolism and in nervous system development and function. The VLDL receptor structure is more or less homologous to that LDL receptor, excluding the eightfold repeated ligand binding domain of VLDLR, which is sevenfold in LDLR. The protein sequence of VLDLR is mostly conserved among mammals such as rabbit, human and mouse. The gene is mapped to human chromosome 9p24.2.
Biochem/physiol Actions
Very-low-density-lipoprotein receptor (VLDLR) is associated with the metabolism of triglyceride rich lipoproteins (VLDL,β-migrating VLDL and intermediate-density lipoprotein) involving apoprotein-E. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. Deletion in the VLDLR gene results in cerebellar hypoplasia an autosomal recessive syndrome. VLDLR gene is significantly associated with Reelin pathway.
Physical form
Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mouse very?low?density?lipoprotein receptor (VLDLR) cDNA cloning, tissue?specific expression and evolutionary relationship with the low?density?lipoprotein receptor.
Oka K, et al.
European Journal of Biochemistry, 224(3), 975-982 (1994)
Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification.
Boycott K M, et al.
American Journal of Human Genetics, 77(3), 477-483 (2005)
Reelin is a ligand for lipoprotein receptors.
D'Arcangelo G, et al.
Neuron, 24(2), 471-479 (1999)
Decreased expression of VLDLR is inversely correlated with miR?200c in human colorectal cancer.
Kim B K, et al.
Molecular Carcinogenesis, 56(6), 1620-1629 (2017)
Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis.
Takada H, et al.
Oncogene, 25(49), 6554-6554 (2006)
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