CTLA4/CD152 human

CTLA4 (cytotoxic T-lymphocyte associated protein 4) or CD152 (cluster of differentiation) is a T cell receptor which belongs to the immunoglobulin (Ig) superfamily or CD28 family. It is expressed on the surface of Th (T helper) cells. This gene is localized to human chromosome 2q33. This protein is composed of a cytosolic domain, a transmembrane region, and a V domain of 116 amino acids. Alternative splicing results in membrane and soluble forms, where membrane forms work as homodimers and soluble isoforms as monomers.

CTLA4 (cytotoxic T-lymphocyte associated protein 4) is responsible for inhibiting T-cell proliferation and facilitates T cell apoptosis. This protein is expressed post-antigen presentation, and thus, is involved in immune and auto-immune disorders. Therefore, it is also implicated in the pathogenesis of various T cell mediated autoimmune disorders. Studies in Baghdadi or Iraqi population show that polymorphism in this gene is linked with susceptibility to diabetes mellitus type I.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.