SRP6509
Chymotrypsin from human pancreas
≥95% (SDS-PAGE)
Synonym(s):
CLCR, CTRC, CTRC_HUMAN, Caldecrin, Chymotrypsin C, Chymotrypsin-C, ELA 4, Elastase 4, Elastase IV, Serum calcium decreasing factor
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About This Item
UNSPSC Code:
12352204
EC Number:
232-671-2
NACRES:
NA.78
Product Name
Chymotrypsin from human pancreas, ≥95% (SDS-PAGE)
biological source
human
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
25 kDa
packaging
pkg of 100 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CTRC(11330)
Biochem/physiol Actions
Chymotrypsin from human pancreas selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan and leucine. Loss-of-function mutations in this gene have been associated with increased risk of chronic pancreatitis. It has high activity toward leucyl peptide bonds. The enzyme acts as a co-activator of procarboxypeptidases A1 and A2.
General description
Chymotrypsin from human pancreas is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. It is secreted by the pancreas as inactive chymotrypsinogen C. Molecular weight of this enzyme is found to be 25kDa. The pI is 8.75.
Physical form
Lyophilized as a salt-free solid.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 1
Regulatory Information
高风险级别生物产品--人源产品
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Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Szabo A
The Journal of Biological Chemistry, 290(28), 17282-17292 (2015)
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