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SRP6518

Sigma-Aldrich

Plasminogen from human plasma

≥95% (SDS-PAGE)

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Synonym(s):
PLG
NACRES:
NA.32

biological source

human

Assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

90.0 – 92.0 kDa

packaging

pkg of 1 mg

UniProt accession no.

P00747

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PLG(5340)

Related Categories

General description

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

Biochem/physiol Actions

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Physical form

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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25G
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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Minor Role of Plasminogen in Complement Activation on Cell Surfaces.
Hyvarinen S and Jokiranta TS
PLoS ONE, 10, e0143707-e0143707 (2015)
Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.
Lee SH, et al.
Biomaterials, 29, 2962-2968 (2008)
Matrix metalloproteinase-1 and -9 activation by plasmin regulates a novel endothelial cell-mediated mechanism of collagen gel contraction and capillary tube regression in three-dimensional collagen matrices.
Davis GE, et al.
Journal of Cell Science, 114, 917-930 (2001)
Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
Inoue K, et al.
The Journal of Biological Chemistry, 274, 27069-27075 (1999)
Molecular characterisation of the human apo (a)-plasminogen gene family clustered on the telomeric region of chromosome 6 (6q26?27).
Magnaghi P, et al.
Human Molecular Genetics, 3(3), 437-442 (1994)
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