SRP6518
Plasminogen from human plasma
≥95% (SDS-PAGE)
Synonym(s):
PLG
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biochem/physiol Actions
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).
General description
Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.
Physical form
Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta.
Odekon LE, et al.
Journal of Cellular Physiology, 158, 398-407 (1994)
Minor Role of Plasminogen in Complement Activation on Cell Surfaces.
Hyvarinen S and Jokiranta TS
PLoS ONE, 10, e0143707-e0143707 (2015)
Genetic linkage between lipoprotein (a) phenotype and a DNA polymorphism in the plasminogen gene.
Drayna D T, et al.
Genomics, 3(3), 230-236 (1988)
Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.
Lee SH, et al.
Biomaterials, 29, 2962-2968 (2008)
Dante Disharoon et al.
Journal of thrombosis and haemostasis : JTH, 20(2), 486-497 (2021-12-10)
To reestablish blood flow in vessels occluded by clots, tissue plasminogen activator (tPA) can be used; however, its efficacy is limited by transport to and into a clot and by the depletion of its substrate, plasminogen. To overcome these rate
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