SRP6523
ApoJ/Clusterin from mouse
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
AAG4, Apolipoprotein J, CLI, CLU, KUB1, MGC24903, SGP-2, SGP2, TRPM-2, TRPM2
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
≥90% (SDS-PAGE)
Form:
liquid
Mol wt:
~45 kDa (Mouse nuclear Clusterin aa 22- 448 is fused at the C-terminus to a His-tag.)
Impurities:
<1 EU/μg endotoxin (LAL test)
biological source
mouse
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
~45 kDa (Mouse nuclear Clusterin aa 22- 448 is fused at the C-terminus to a His-tag.)
packaging
pkg of 10 μg, pkg of 50 μg
concentration
1 mg/mL
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... CLU(12759)
General description
Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
Physical form
1 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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