SRP6549
Alkaline Phosphatase from calf intestine
≥98% (SDS-PAGE)
Synonym(s):
ALP, ALP-1, ALPP, ALPPL, ALPPL2, PALP, PLAP, PLAP-1
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About This Item
EC Number:
232-631-4
UNSPSC Code:
12352205
Biological source:
bovine (calf) intestine
Assay:
≥98% (SDS-PAGE)
Form:
freeze-dried protein glass
Impurities:
3000-6,000 EU/μg endotoxin (LAL test)
biological source
bovine (calf) intestine
assay
≥98% (SDS-PAGE)
form
freeze-dried protein glass
packaging
pkg of 1 mg, pkg of 10 μg, pkg of 50 μg
impurities
3000-6,000 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
bovine (calf) ... ALPL(280994)
General description
Alkaline phosphatase (ALP) is a hydrolase enzyme. It is a highly active form in calf intestinal mucosa. The calf intestinal alkaline phosphatase is a dimeric glycoprotein with a molecular weight of about 140kDa.
Application
Alkaline phosphatase from calf intestine has been used as a standard in alkaline phosphatase assay.
Biochem/physiol Actions
Alkaline phosphatase (ALP) is responsible for removing phosphate groups at the 5- and 3- positions from many types of molecules, such as nucleotides, proteins, and alkaloids. It can also modify lipopolysaccharides by dephosphorylation of the lipid A moiety, thereby making it less toxic than the unmodified lipid A.
Physical form
Lyophilized without any additives.
Preparation Note
Reconstitute in distilled water or dilute buffer.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
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Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota.
Cell host & microbe, 2, 371-382 (2007)
Quantitation of surface coverage of oligonucleotides bound to chip surfaces: a fluorescence-based approach using alkaline phosphatase digestion.
Pal S
Lab on a chip, 8, 1332-1341 (2008)
Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity.
Addison WN
The Journal of Biological Chemistry, 282, 15872-15883 (2007)
Affinity-chromatography purification of alkaline phosphatase from calf intestine.
Brenna O
The Biochemical Journal, 151, 291-296 (1975)
Intestinal alkaline phosphatase. Physical properties and quaternary structure.
M Fosset et al.
Biochemistry, 13(9), 1783-1788 (1974-04-23)
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