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Merck
CN

SRP6585

Sigma-Aldrich

Histone H2B (1-123) from Xanopus sp.

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

HIST1H2BA, Histone H2B type 1-A, TSH2B

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

Key Documents

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biological source

Xenopus laevis

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

13.7 kDa (1-123 aa)

packaging

pkg of 100 and 250 μg

UniProt accession no.

Q96A08

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... H2B1A(255626)

General description

H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H2B undergoes many modifications which include acetylation, phosphorylation, ubiquitylation, sumoylation, and biotinylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.

Physical form

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 300 mM sodium chloride, 1 mM DTT, 1 mM EDTA and 20% glycerol.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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