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Merck
CN

SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG® tagged, >90% (SDS-PAGE)

Synonym(s):

AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352202

Key Documents

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Product Name

GITRL, Soluble mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >90% (SDS-PAGE)

biological source

mouse

recombinant

expressed in HEK 293 cells

tag

FLAG® tagged

assay

>90% (SDS-PAGE)

form

liquid

mol wt

~22 kDa by SDS-PAGE

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

≥0.2 mg/mL

impurities

<0.1 EU/μg endotoxin, tested

color

clear

UniProt accession no.

Q7TS55

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Tnfsf18(240873)

General description

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Other Notes

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.

Physical form

Solution in 10 mM glycine, pH 10.0.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
132B6D5

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