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Merck
CN

T0516

Thromboxane B2

Synonym(s):

(5Z,9α,11RS,13E,15S)-9,11,15-Trihydroxythromboxa-5,13-dien-1-oic acid, TXB2

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About This Item

Empirical Formula (Hill Notation):
C20H34O6
CAS Number:
54397-85-2
Molecular Weight:
370.48
UNSPSC Code:
12352200
PubChem Substance ID:
24899894
MDL number:
MFCD00135258

Key Documents

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InChI

1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1

SMILES string

CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

InChI key

XNRNNGPBEPRNAR-JQBLCGNGSA-N

assay

≥98% (HPLC)

form

powder

functional group

carboxylic acid

shipped in

ambient

storage temp.

−20°C

Biochem/physiol Actions

Prostaglandin derivative that is released during anaphylaxis; induces arterial contraction and platelet aggregation.
Prostaglandin derivative that is released during anaphylaxis; induces arterial contraction and platelet aggregation. Review of endogenous thromboxane B2 in risk analysis for development of thrombogenic disorders.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBD5303V
SLBC2766V
021M1501V
021M1501
020M1154

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Yan Huang et al.
Molecular cancer therapeutics, 15(12), 2894-2904 (2016-09-18)
To determine the efficacy of a novel and safer (for gastrointestinal tract) aspirin (aspirin-PC) in preclinical models of ovarian cancer, in vitro dose-response studies were performed to compare the growth-inhibitory effect of aspirin-PC versus aspirin on three human (A2780, SKOV3ip1
Haowen Zhang et al.
European journal of pharmacology, 794, 234-245 (2016-11-30)
High on-aspirin platelet reactivity (HAPR) has been associated with compromised aspirin efficacy in patients with diabetes suffering from acute cardiovascular events, but the key mechanisms remain elusive. The objective of this study was to uncover the potential link between pathogenic
C R Pace-Asciak et al.
Clinica chimica acta; international journal of clinical chemistry, 246(1-2), 163-182 (1996-03-15)
To test the hypothesis that red wine, by virtue of its relatively high concentration of polyphenols, is more protective against atherosclerosis and coronary heart disease (CHD) than white wine, and that grape juice enriched in one of these, trans-resveratrol, may
Karl Wilhelm Olsson et al.
Pediatric research, 86(3), 333-338 (2018-10-06)
Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persistence of PDA, and with failure of pharmacological treatment for PDA
M Naegele et al.
International journal of cardiology, 224, 226-230 (2016-10-25)
Takotsubo syndrome (TTS) is an acute cardiomyopathy associated with intense physical or emotional stress. The precise mechanisms of the disease remain unclear. The aim of this study was to study alterations in endothelial function, vascular compliance and structure and muscle
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