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Merck
CN

T0675

[D-Ala2]-Deltorphin II

≥97% (HPLC)

Synonym(s):

Tyr-D-Ala-Phe-Glu-Val-Val-Gly amide

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About This Item

Empirical Formula (Hill Notation):
C38H54N8O10
CAS Number:
122752-16-3
Molecular Weight:
782.88
NACRES:
NA.32
PubChem Substance ID:
24899907
UNSPSC Code:
12352209
MDL number:
MFCD00080072
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
synthetic (organic)

Key Documents

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Product Name

[D-Ala2]-Deltorphin II, ≥97% (HPLC)

InChI

1S/C38H54N8O10/c1-20(2)31(37(55)41-19-29(40)48)46-38(56)32(21(3)4)45-35(53)27(15-16-30(49)50)43-36(54)28(18-23-9-7-6-8-10-23)44-33(51)22(5)42-34(52)26(39)17-24-11-13-25(47)14-12-24/h6-14,20-22,26-28,31-32,47H,15-19,39H2,1-5H3,(H2,40,48)(H,41,55)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H,46,56)(H,49,50)/t22-,26+,27+,28+,31+,32+/m1/s1

SMILES string

CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)C)C(=O)NCC(N)=O

InChI key

NUNBRHVOPFWRRG-RCEFDBTISA-N

biological source

synthetic (organic)

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

Quality Level

200

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprd1(18386), Oprm1(18390)
rat ... Oprd1(24613), Oprm1(25601)

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Biochem/physiol Actions

Selective δ2 opioid receptor agonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCC1825
SLBZ8418
SLBS8359
SLBR8129V
SLBP5876V

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A Capasso
Medicinal chemistry (Shariqah (United Arab Emirates)), 5(1), 1-6 (2009-01-20)
Recently, we have demonstrated that substitution of 1,2,3,4 tetrahyidroisoquinoline-3- carboxylic acid (Tic) in place of Gly2 in dynorphin A-(1-13)-NH2 (DYN) analogue (A) decreased the affinity to the kappa, delta, and micro receptors, and kappa selectivity. The doubly substituted analogue [2',6'-dimethyl-L-tyrosine
Michael A Ansonoff et al.
Psychopharmacology, 210(2), 161-168 (2010-03-25)
During the past decade, substantial evidence has documented that opioid receptor heterodimers form in cell lines expressing one or more opioid receptors. More recent studies have begun to investigate whether heterodimer formation also occurs in vivo. We have used opioid
Leonid N Maslov et al.
Life sciences, 84(19-20), 657-663 (2009-02-28)
This study aims to investigate the role of peripheral delta(2) opioid receptors in cardiac tolerance to ischemia/reperfusion injury and to examine the contribution of PKC, TK, K(ATP) channels and the autonomic nervous system in delta(2) cardioprotection. Deltorphin II and various
Aaron C Overland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13264-13273 (2009-10-23)
Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the alpha(2A)ARs are
Michael M Morgan et al.
Neural plasticity, 2009, 516328-516328 (2009-03-07)
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will allow antinociception to the
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