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T0702

D-γ-Tocotrienol

Name: <SC>D</SC>-γ-Tocotrienol
Brand: SIGMA

from palm oil, ≥80% (GC)

Synonym(s):

(R-(all-E))-3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12,16,20,24,28,32-octamethyl-3,7,11,15,19,23,27,31-tritriacontaoctaenyl)-2H-1-benzopyran-6-ol

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₄₂O₂

CAS Number:

14101-61-2

Molecular Weight:

410.63

UNSPSC Code:

12352200

MDL number:

MFCD05864856

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Properties

biological source

palm oil

assay

≥80% (GC)

storage temp.

−20°C

SMILES string

C/C(CC/C=C(C)/CCC=C(C)C)=C\CC[C@@]1(C)OC2=C(C)C(C)=C(O)C=C2CC1

InChI

1S/C28H42O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1

InChI key

OTXNTMVVOOBZCV-WAZJVIJMSA-N

Description

Biochem/physiol Actions

Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. In addition to its antioxidant properties γ-tocotrienol has been shown to inhibit the NF-κB activation pathway. γ-tocotrienol also acts as an inhibitor of HMG-CoA, the rate limiting enzyme in cholesterol biosynthesis.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?

Maaike Berbée et al.

Current opinion in supportive and palliative care, 6(1), 54-59 (2012-01-10)

To give an overview of promising novel agents under development for the prevention and reduction of gastrointestinal radiation injury. Currently, several novel agents are being tested as drugs to prevent or reduce gastrointestinal radiation injury. These drugs may not only

[Chloroplast prenylated lipids in response to stress in plants].

Renata Szymańska

Postepy biochemii, 58(4), 372-376 (2012-01-01)

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.

Kanjoormana A Manu et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 18(8), 2220-2229 (2012-02-22)

Because of poor prognosis and development of resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective. Hence, novel agents that are safe and effective are urgently needed. Whether γ-tocotrienol can sensitize gastric cancer to capecitabine in

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