T0892
Interleukin-2 from rat
from rat, suitable for cell culture
Synonym(s):
rIL-2, IL-2, T-Cell growth factor, IL-2
biological source
rat
form
solid
potency
0.2-2.5 units/mL
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
2-8°C
Gene Information
rat ... Il2(116562)
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Biochem/physiol Actions
Interleukin-2 is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. Interleukin-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1 mg bovine serum albumin
Preparation Note
Purified from a conditioned medium of a rat splenocyte culture stimulated by concanavalin A.
Other Notes
One unit is the amount required to induce half-maximal incorporation of 3H-thymidine into IL-2-dependent cytolytic T cell lymphocytes.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M D Jyothi et al.
Scandinavian journal of immunology, 52(2), 148-155 (2000-08-10)
We have previously shown that inducible nitric oxide synthase (iNOS) was up-regulated in natural killer (NK) cells when AK-5 tumour cells were transplanted subcutaneously into syngeneic Wistar rats. This study was designed to investigate the role of interleukin (IL)-2 during
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