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Merck
CN

T0892

Sigma-Aldrich

Interleukin-2 from rat

from rat, suitable for cell culture

Synonym(s):

rIL-2, IL-2, T-Cell growth factor, IL-2

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About This Item

CAS Number:
95568-40-4
MDL number:
MFCD00131401
UNSPSC Code:
12352200

Key Documents

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biological source

rat

form

solid

potency

0.2-2.5 units/mL

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P04351

storage temp.

2-8°C

Gene Information

rat ... Il2(116562)

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Biochem/physiol Actions

Interleukin-2 is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of activated T cells and related cell types. Interleukin-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 1 mg bovine serum albumin

Preparation Note

Purified from a conditioned medium of a rat splenocyte culture stimulated by concanavalin A.

Other Notes

One unit is the amount required to induce half-maximal incorporation of 3H-thymidine into IL-2-dependent cytolytic T cell lymphocytes.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
062K1193
104H00061
071K1148
061K0273

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M D Jyothi et al.
Scandinavian journal of immunology, 52(2), 148-155 (2000-08-10)
We have previously shown that inducible nitric oxide synthase (iNOS) was up-regulated in natural killer (NK) cells when AK-5 tumour cells were transplanted subcutaneously into syngeneic Wistar rats. This study was designed to investigate the role of interleukin (IL)-2 during

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