T102
MDL-72222
≥96% (HPLC), solid
Synonym(s):
3-Tropanyl-3,5-dichlorobenzoate
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About This Item
Empirical Formula (Hill Notation):
C15H17Cl2NO2
CAS Number:
Molecular Weight:
314.21
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥96% (HPLC)
form
solid
color
white
solubility
0.1 M HCl: slightly soluble, DMSO: soluble, H2O: insoluble
Gene Information
rat ... Htr3a(79246)
Application
MDL-72222 may be used in 5-HT receptor-mediated cell signaling studies.
Biochem/physiol Actions
MDL-72222 is specific for the peripheral neuronal 5-hydroxytryptamine receptors of mammals. It suppresses voluntary ethanol consumption that is mediated by the 5-HT3 receptor.
Selective 5HT3 serotonin receptor antagonist.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Yuji Omiya et al.
Journal of pharmacological sciences, 99(4), 373-380 (2005-11-30)
In this study, the antinociceptive effect of shakuyakukanzoto was investigated using streptozotocin-induced diabetic mice to certify its analgesic effect on diabetic patients. Shakuyakukanzoto (0.5 and 1.0 g/kg, p.o.) significantly increased the nociceptive threshold in diabetic mice. The antinociceptive activity of
J R Fozard
Naunyn-Schmiedeberg's archives of pharmacology, 326(1), 36-44 (1984-05-01)
The properties of MDL 72222 (1 alpha H, 3 alpha, 5 alpha H-tropan-3-yl-3,5-dichlorobenzoate), a novel compound with potent and selective blocking actions at certain excitatory 5-hydroxytryptamine (5-HT) receptors on mammalian peripheral neurones, are described. On the rabbit isolated heart, MDL
Ji-Hoon Yoo et al.
Synapse (New York, N.Y.), 62(1), 8-13 (2007-10-24)
We have previously shown that 5-HT3 receptors are involved in the development and expression of methamphetamine (MAP)-induced locomotor sensitization in mice. In the present study, we further examined whether the dopaminergic system is involved in the attenuating effects of MDL
Ryo Kawai et al.
Zoological science, 28(7), 517-525 (2011-07-07)
In the central nervous system of the pond snail Lymnaea stagnalis, serotonergic transmission plays an important role in controlling feeding behavior. Recent electrophysiological studies have claimed that only metabotropic serotonin (5-HT(2)) receptors, and not ionotropic (5-HT(3)) receptors, are used in
Xiaoqin Zhang et al.
Biochimica et biophysica acta, 1823(12), 2157-2167 (2012-09-04)
Stress hormone, glutamatergic system, serotonergic system and the noradrenergic system are involved in depressive disorders. However, the relationship among these is still unclear. The present study examined the effect of dexamethasone (DEX) on the presynaptic glutamate release of synaptosomes from
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