T102
MDL-72222
≥96% (HPLC), solid
Synonym(s):
3-Tropanyl-3,5-dichlorobenzoate
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About This Item
Empirical Formula (Hill Notation):
C15H17Cl2NO2
CAS Number:
Molecular Weight:
314.21
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥96% (HPLC)
form
solid
color
white
solubility
0.1 M HCl: slightly soluble
DMSO: soluble
H2O: insoluble
Gene Information
rat ... Htr3a(79246)
Application
MDL-72222 may be used in 5-HT receptor-mediated cell signaling studies.
Biochem/physiol Actions
MDL-72222 is specific for the peripheral neuronal 5-hydroxytryptamine receptors of mammals. It suppresses voluntary ethanol consumption that is mediated by the 5-HT3 receptor.
Selective 5HT3 serotonin receptor antagonist.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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F Fadda et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 26(2), 107-110 (1991-01-01)
The effect of the selective 5-HT3 receptor antagonist MDL 72222 on voluntary ethanol consumption was examined in Sardinian ethanol-preferring (SP) rats in a free choice (10% ethanol and water) experiment. SP rats consumed 8.1 +/- 1.1 g/kg ethanol daily. MDL
Satoshi Hagiwara et al.
European journal of pain (London, England), 13(3), 249-252 (2008-06-10)
Pulsed radiofrequency (PRF) has been reported to be effective in the treatment of several types of pain. The mechanism of action, however, is not well known. In a recent study, the antinociceptive effects of acute thermal pain were shown to
Esa Meririnne et al.
Basic & clinical pharmacology & toxicology, 98(4), 346-350 (2006-04-21)
1-Benzylpiperazine (also known as 'Legal X', 'Legal E', or 'A2') is a psychoactive compound increasingly encountered on the clandestine market. Previous experimental data suggest that the compound possesses addictive properties. In the present study, we used the conditioned place preference
Wen Liu et al.
Pharmacology, biochemistry, and behavior, 84(2), 370-377 (2006-07-11)
A previous study indicated that pretreatment with repeated daily injections of serotonin-3 (5-HT3) receptor antagonists subsequently reduced the effectiveness of the 5-HT3 antagonists to attenuate ethanol intake under 24-h free-choice conditions; one possibility to account for this is that the
Karim A Alkadhi et al.
Brain research, 1234, 25-31 (2008-08-23)
Long-term depression (LTD) is a use-dependent decrease in synaptic efficacy widely recognized as a form of synaptic plasticity related to cognitive function in the central nervous system. Such response has previously not been demonstrated in autonomic ganglia. In the isolated
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