T133
Inactin® hydrate
≥98% (HPLC), Anethetic reagent, powder
Synonym(s):
Thiobutabarbital sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C10H15N2NaO2S · xH2O
CAS Number:
Molecular Weight:
250.29 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-425-3
MDL number:
Product Name
Inactin® hydrate, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada
color
light yellow
solubility
H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)
SMILES string
[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O
InChI
1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1
InChI key
SLZHLQUFNFXTHB-UHFFFAOYSA-M
Application
Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity and mice to study Cisplatin-induced neuropathy. It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).
Biochem/physiol Actions
Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.
Legal Information
Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Maki Niihori et al.
American journal of respiratory cell and molecular biology, 62(2), 231-242 (2019-08-29)
NFU1 is a mitochondrial protein that is involved in the biosynthesis of iron-sulfur clusters, and its genetic modification is associated with disorders of mitochondrial energy metabolism. Patients with autosomal-recessive inheritance of the NFU1 mutation G208C have reduced activity of the
Min-Suk Yoon et al.
BMC neuroscience, 10, 77-77 (2009-07-16)
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy
Flecknell
Laboratory Animal Anesthesia. An introduction for Research Workers and Technicians, 36-36 (1987)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB1306335-400UL | 04061835642977 |
| T133-5X1G | 04061832561295 |
| T133-1G | 04061826203996 |
| T133-25X1G | 04061837337178 |