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Merck
CN

T133

Sigma-Aldrich

Inactin® hydrate

≥98% (HPLC)

Synonym(s):

Thiobutabarbital sodium salt hydrate

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¥226.99
100 G
¥686.80

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25 G
¥226.99
100 G
¥686.80

About This Item

Empirical Formula (Hill Notation):
C10H15N2NaO2S · xH2O
CAS Number:
Molecular Weight:
250.29 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

¥226.99


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Quality Level

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

color

light yellow

solubility

H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.)

SMILES string

[Na+].CCC(C)C1(CC)C([O-])=NC(=S)NC1=O

InChI

1S/C10H16N2O2S.Na/c1-4-6(3)10(5-2)7(13)11-9(15)12-8(10)14;/h6H,4-5H2,1-3H3,(H2,11,12,13,14,15);/q;+1/p-1

InChI key

SLZHLQUFNFXTHB-UHFFFAOYSA-M

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This Item
125881100900411973
assay

98%

assay

98%

assay

97%

assay

96%

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

refractive index

n20/D 1.625 (lit.)

refractive index

-

refractive index

-

refractive index

-

mp

15-18 °C (lit.)

mp

51-53 °C (lit.)

mp

56-62 °C (lit.)

mp

68-71 °C (lit.)

density

1.58 g/mL at 25 °C (lit.)

density

-

density

-

density

-

form

liquid

form

solid

form

solid

form

-

Application

Inactin® hydrate has been used to anesthetize rats to study stress-induced hypersensitivity[1] and mice to study Cisplatin-induced neuropathy.[2] It has also been used to anesthetize rats to measure the glomerular filtration rate (GFR).[3]

Biochem/physiol Actions

Inactin® is a long-lasting rodent anesthetic with minimal effects on cardiovascular tone and renal output. It exhibits sedative and hypnotic properties.

Legal Information

Inactin is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Hye Jin Kim et al.
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Direct analysis in real time (DART) ion source is a powerful ionising technique for the quick and easy detection of various organic molecules without any sample preparation steps, but the lack of quantitation capacity limits its extensive use in the
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Phytotherapy research : PTR, 25(3), 435-443 (2010-08-27)
Aggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and
Meng-Shiou Lee et al.
Molecules (Basel, Switzerland), 18(1), 354-372 (2012-12-29)
Glutamate-induced excitotoxicity has been implicated in a variety of neuronal degenerative disorders. In the present study, we investigated the possible neuroprotective effects of schizandrin against apoptosis of primary cultured rat cortical cells induced by glutamate. Glutamate (10 μM) administered for
Di Hu et al.
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In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta(1-42)- (Aβ(1-42)-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ(1-42) and then
Elina Hakala et al.
The Journal of antibiotics, 68(10), 609-614 (2015-05-07)
Lignans from Schisandra chinensis berries show various pharmacological activities, of which their antioxidative and cytoprotective properties are among the most studied ones. Here, the first report on antibacterial properties of six dibenzocyclooctadiene lignans found in Schisandra spp. is presented. The

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