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Merck
CN

T1427

Triprolidine hydrochloride

Sigma Reference Standard

Synonym(s):

(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H22N2 · HCl
CAS Number:
6138-79-0
Molecular Weight:
314.85
UNSPSC Code:
12352200
PubChem Substance ID:
329826672
MDL number:
MFCD00039044

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InChI

1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

SMILES string

CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl

InChI key

WYUYEJNGHIOFOC-NWBUNABESA-N

packaging

vial of 500 mg

solubility

H2O: moderately soluble, ethanol: moderately soluble, methanol: moderately soluble

Gene Information

human ... HRH1(3269)

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Application

Triprolidine hydrochloride has been used as a histamine H1 ligand to assess its affinity for [125I]-iodophenpropit binding sites. Furthermore, triprolidine has also been used to evaluate quantitative structure-retention relationships of antihistamine drugs chromatographed on α1-acid glycoprotein columns.

Biochem/physiol Actions

H1 histamine receptor antagonist.

Packaging

Supplied in amber screw-cap vials

Preparation Note

Triprolidine hydrochloride is moderately soluble in methanol, ethanol and water.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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R Kaliszan et al.
Journal of chromatography. A, 722(1-2), 25-32 (1996-01-26)
Quantitative relationships between the structure of antihistamine drugs (AHD) and their retention on an alpha 1-acid glycoprotein (AGP) HPLC column (QSRR) were studied in order to identify characteristic structural features of the binding site for AHD on AGP. The hydrophobicity
F P Jansen et al.
British journal of pharmacology, 113(2), 355-362 (1994-10-01)
1. The binding of the first selective radiolabelled histamine H3-receptor antagonist [125I]-iodophenpropit to rat cerebral cortex membranes was characterized. 2. [125I]-iodophenpropit, radiolabelled to a high specific activity of 1900 Ci mmol-1, saturably bound to a single class of sites with
Y-N Song et al.
Neuroscience, 140(1), 33-43 (2006-03-15)
Previous studies have revealed a direct histaminergic projection from the tuberomamillary nucleus of hypothalamus to the cerebellum and a postsynaptic excitatory effect of histamine on the cerebellar interpositus nucleus neurons via histamine H(2) receptors in vitro, indicating that the histaminergic
Ashok K Shakya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(32), 4071-4078 (2009-11-21)
A highly efficient, selective and specific method for simultaneous quantitation of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap-tandem mass spectrometry coupled with electro spray ionization (LC-ESI-ion trap-tandem MS) has been validated and successfully applied to a clinical
Adnan Manassra et al.
Journal of pharmaceutical and biomedical analysis, 51(4), 991-993 (2009-12-04)
An HPLC method using UV detection is proposed for the simultaneous determination of pseudophedrine hydrochloride, codeine phosphate, and triprolidine hydrochloride in liquid formulation. C18 column (250mmx4.0mm) is used as the stationary phase with a mixture of methanol:acetate buffer:acetonitrile (85:5:10, v/v)
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