T1516
DL-Trihexyphenidyl hydrochloride
solid
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About This Item
Empirical Formula (Hill Notation):
C20H31NO · HCl
CAS Number:
Molecular Weight:
337.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
solid
Quality Level
color
white
solubility
methanol: soluble 50 mg/ml, clear to hazy, colorless, H2O: soluble
SMILES string
Cl[H].OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3
InChI
1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
InChI key
QDWJJTJNXAKQKD-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
Application
DL-Trihexyphenidyl hydrochloride has been used to develop a capillary zone electrophoretic method with end-column electrochemiluminescence (ECL)-based detection technique.
Biochem/physiol Actions
DL-trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is known to function as an antimuscarinic agent and a centrally acting anticholinergic. It can be used for controlling the symptoms of all Parkinsonism types, such as the idiopathic, and postencephalitic arteriosclerotic forms. Benzhexol hydrochloride exerts inhibitory functions on the parasympathetic nervous system.
Muscarinic acetylcholine receptor antagonist
Preparation Note
DL-Trihexyphenidyl hydrochloride is soluble in water. It dissolves in methanol at 50 mg/ml to yield a clear to hazy, colorless solution.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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T Hayakawa et al.
Clinical and experimental pharmacology & physiology, 26(5-6), 421-425 (1999-07-01)
1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats. 2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 micrograms) into the medial forebrain bundle at
H E Shannon et al.
The Journal of pharmacology and experimental therapeutics, 290(2), 901-907 (1999-07-20)
The purpose of our studies was to determine the effects of muscarinic receptor agonists on conditioned avoidance responding in the rat. Rats were trained to avoid or escape an electric shock delivered to the feet in a discrete trial procedure.
Determination of benzhexol hydrochloride by capillary zone electrophoresis with an end-column electrochemiluminescence detection.
Yan, J., et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 76(1), 11-16 (2004)