T154
Tityustoxin-Kα from Tityus serrulatus (Brazilian scorpion) venom
lyophilized powder
form
lyophilized powder
solubility
H2O: soluble
storage temp.
−20°C
Gene Information
human ... KCNS1(3787), KCNS2(3788)
mouse ... KCNS1(16538), KCNS2(16539)
rat ... KCNS1(117023), KCNS2(66022)
Amino Acid Sequence
Val-Phe-Ile-Asn-Ala-Lys-Cys-Arg-Gly-Ser-Pro-Glu-Cys-Leu-Pro-Lys-Cys-Lys-Glu-Ala-Ile-Gly-Lys-Ala-Ala-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro
Biochem/physiol Actions
Potent and selective voltage-gated non-inactivating (delayed-rectifier) K+ channel blocker.
Legal Information
Sold under license from the University of Maryland.
Disclaimer
Hygroscopic, photosensitive. Only plastic tubes should be used with this product.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Alessandro Grottesi et al.
FEBS letters, 535(1-3), 29-33 (2003-02-01)
Toxins that block voltage-gated potassium (Kv) channels provide a possible template for improved homology models of the Kv pore. In assessing the interactions of Kv channels and their toxins it is important to determine the dynamic flexibility of the toxins.
Adolfo Borges et al.
Parasitology research, 99(2), 167-173 (2006-03-16)
Leishmania parasites are sensitive to peptides with antimicrobial and ion-channel inhibitory activity. Because scorpion venoms are rich sources of such peptides, the leishmanicidal effect of Tityus discrepans venom was investigated. A negative correlation between cell growth and venom concentration was
Michel B S Mesquita et al.
Toxicology and applied pharmacology, 187(1), 58-66 (2003-03-12)
In this work we submitted adult male Wistar rats to intracerebroventricular (icv) and iv microinjections of the fraction tityostoxin (TsTX) from the Tityus serrulatus scorpion venom, to address whether the CNS could account for the systemic alterations previously reported: cardiac
Andréa C Pessini et al.
Toxicon : official journal of the International Society on Toxinology, 48(5), 556-566 (2006-08-17)
Tityus serrulatus venom (Tsv) was intraperitoneally (ip) injected at doses of 75, 150 and 300mug/kg and IL-1beta (2.0 microg/kg) was given intravenously (iv) to male Wistar rats. Rectal temperature was measured by radiotelemetry. Vagotomy was performed according to Bluthe et
Ana Leonor A Nencioni et al.
Pharmacology, biochemistry, and behavior, 74(2), 455-463 (2002-12-14)
Scorpion toxins act on ionic channels changing the release of neurotransmitters. In the present study, we investigated the glutamatergic release evoked by intrahippocampal injection of TsTX toxin isolated from Tityus serrulatus scorpion venom in male Wistar rats and the blockade
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service