T154
Tityustoxin-Kα from Tityus serrulatus (Brazilian scorpion) venom
lyophilized powder
form
lyophilized powder
solubility
H2O: soluble
storage temp.
−20°C
Gene Information
human ... KCNS1(3787), KCNS2(3788)
mouse ... KCNS1(16538), KCNS2(16539)
rat ... KCNS1(117023), KCNS2(66022)
Biochem/physiol Actions
Potent and selective voltage-gated non-inactivating (delayed-rectifier) K+ channel blocker.
Legal Information
Sold under license from the University of Maryland.
Disclaimer
Hygroscopic, photosensitive. Only plastic tubes should be used with this product.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Michel B S Mesquita et al.
Toxicology and applied pharmacology, 187(1), 58-66 (2003-03-12)
In this work we submitted adult male Wistar rats to intracerebroventricular (icv) and iv microinjections of the fraction tityostoxin (TsTX) from the Tityus serrulatus scorpion venom, to address whether the CNS could account for the systemic alterations previously reported: cardiac
Adolfo Borges et al.
Parasitology research, 99(2), 167-173 (2006-03-16)
Leishmania parasites are sensitive to peptides with antimicrobial and ion-channel inhibitory activity. Because scorpion venoms are rich sources of such peptides, the leishmanicidal effect of Tityus discrepans venom was investigated. A negative correlation between cell growth and venom concentration was
Chie-Fang Hsiao et al.
Journal of neurophysiology, 101(3), 1407-1418 (2009-01-16)
The function and biophysical properties of low threshold Kv1 current in control of membrane resonance, subthreshold oscillations, and bursting in mesencephalic V neurons (Mes V) were examined in rat brain stem slices (P8-P12) using whole cell current and voltage patch-clamp
Alessandro Grottesi et al.
FEBS letters, 535(1-3), 29-33 (2003-02-01)
Toxins that block voltage-gated potassium (Kv) channels provide a possible template for improved homology models of the Kv pore. In assessing the interactions of Kv channels and their toxins it is important to determine the dynamic flexibility of the toxins.
Joseph J Pancrazio et al.
Biosensors & bioelectronics, 18(11), 1339-1347 (2003-08-05)
Cultured neuronal networks, which have the capacity to respond to a wide range of neuroactive compounds, have been suggested to be useful for both screening known analytes and unknown compounds for acute neuropharmacologic effects. Extracellular recording from cultured neuronal networks
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