T1698
Tetradecylthioacetic acid
≥97% (NMR)
Synonym(s):
TTA
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About This Item
Linear Formula:
C14H29-S-CH2COOH
CAS Number:
Molecular Weight:
288.49
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
IPBCWPPBAWQYOO-UHFFFAOYSA-N
SMILES string
CCCCCCCCCCCCCCSCC(O)=O
InChI
1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
assay
≥97% (NMR)
color
white
solubility
DMSO: soluble ≥22 mg/mL
Quality Level
Gene Information
human ... PPARA(5465)
Biochem/physiol Actions
PPARα agonist; activation in ranking order: PPARδ > PPARα > PPARγ
Tetradecylthioacetic acid (TTA) is known to modulate lipid homeostasis. TTA can increase fatty acid oxidation and ketogenesis, which can subsequently prevent adiposity and insulin resistance. Furthermore, TTA can enhance cardiac functions during experimental heart failure.
Features and Benefits
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Packaged under nitrogen.
Preparation Note
Tetradecylthioacetic acid is soluble in DMSO at a concentration that is greater than or equal to 22 mg/ml.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Erik Øie et al.
Lipids, 48(2), 139-154 (2012-12-26)
Changes in myocardial metabolism, including a shift from fatty acid to glucose utilization and changes in fatty acid availability and composition are characteristics of heart failure development. Tetradecylthioacetic acid (TTA) is a fatty acid analogue lacking the ability to undergo
Lise Madsen et al.
Journal of lipid research, 43(5), 742-750 (2002-04-25)
Tetradecylthioacetic acid (TTA) is a non-beta-oxidizable fatty acid analog, which potently regulates lipid homeostasis. Here we evaluate the ability of TTA to prevent diet-induced and genetically determined adiposity and insulin resistance. In Wistar rats fed a high fat diet, TTA
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