T173
Thio-L-citrulline
synthetic, solid
Synonym(s):
(S)-2-Amino-5-(thioureido)pentanoic acid, N5-Aminothioxomethyl-L-ornithine
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C6H13N3O2S
CAS Number:
Molecular Weight:
191.25
UNSPSC Code:
12352204
Beilstein/REAXYS Number:
6844478
MDL number:
biological source
synthetic
form
solid
color
white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
SMILES string
N[C@@H](CCCNC(N)=S)C(O)=O
InChI
1S/C6H13N3O2S/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
InChI key
BKGWACHYAMTLAF-BYPYZUCNSA-N
Biochem/physiol Actions
Potent and selective inhibitor of neuronal and endothelial isoforms of nitric oxide synthase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
E S Furfine et al.
The Journal of biological chemistry, 269(43), 26677-26683 (1994-10-28)
Potent and selective inhibition of neuronal nitric oxide synthase (nNOS) compared to endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia (stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of
H M Abu-Soud et al.
The Journal of biological chemistry, 269(51), 32318-32326 (1994-12-23)
Heme iron reduction in the nitric-oxide synthases (NOSs) requires calmodulin binding and is associated with increased NO synthesis and NADPH oxidation (Abu-Soud, H. M., and Stuehr, D. J. (1993) Proc. Natl. Acad. Sci., U. S. A. 90, 10769-10772). Here, we
C Frey et al.
The Journal of biological chemistry, 269(42), 26083-26091 (1994-10-21)
Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (NO). The enzyme is inhibited by a variety of N omega-monosubstituted L-arginine analogs, and some of these compounds are useful in reversing pathologies associated with the overproduction
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service