T2830
Tomatine hydrate
≥95% (HPLC)
Synonym(s):
Lycopersicin, NSC 234440, NSC 9223, Spirosolane, a-Tomatine, alpha-tomatine, b-D-galactopyranoside deriv
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About This Item
Empirical Formula (Hill Notation):
C50H83NO21 · xH2O
CAS Number:
Molecular Weight:
1034.19 (anhydrous basis)
EC Number:
241-429-5
UNSPSC Code:
12352200
Product Name
Tomatine hydrate, ≥95% (HPLC)
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
Application
Tomatine has been used as a standard for HPLC-based determination of tomatine from red and green tomatoes1. It has also been used to study its teratogenic effect using frog embryos2.
Biochem/physiol Actions
When the pure compounds were isolated, alpha-Tomatine was highly effective in inhibiting all of the cell lines, whereas dehydrotomatine, tomatidenol, and tomatidine had little, if any, effect on cell inhibition. It had been previously shown that commercial tomatine, which is customarily an approximate 10:1 mixture of α-tomatine and dehydrotomatine, strongly inhibits the growth of both colon and liver cancer cells.
It had been previously shown that commercial tomatine, which is customarily an approximate 10:1 mixture of α-tomatine and dehydrotomatine, strongly inhibits the growth of both colon and liver cancer cells.
Preparation Note
Tomatine hydrate is soluble in DMSO at a concentration that is greater than 20 mg/ml.
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Suk Hyun Choi et al.
Journal of agricultural and food chemistry, 60(15), 3891-3899 (2012-04-10)
Partial acid hydrolysis of the tetrasaccharide (lycotetraose) side chain of the tomato glycoalkaloid α-tomatine resulted in the formation of four products with three, two, one, and zero carbohydrate side chains, which were separated by high-performance liquid chromatography (HPLC) and identified
Hideyuki Manabe et al.
Chemical & pharmaceutical bulletin, 59(11), 1406-1408 (2011-11-02)
In the conventional method of mixer blending extraction, the yields of the tomato-saponin, esculeoside A, in the mini and middy tomatoes were found to be 0.043% and 0.046%, respectively. In order to improve the yields, we attempted a more efficient
Kyeong-Mi Choi et al.
The Journal of nutritional biochemistry, 24(1), 335-342 (2012-09-15)
Obesity is a risk factor for numerous metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. In this study, we investigated whether red and green tomato extracts attenuate high-fat-diet-induced obesity in C57BL/6 mice.
Yandong Shi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(17), 4646-4656 (2012-06-27)
The aim of this study was to assess the activity of hedgehog signaling pathway in malignant pleural mesothelioma (MPM). The expression of hedgehog signaling components was assessed by quantitative PCR and in situ hybridization in 45 clinical samples. Primary MPM
J M Medina et al.
Parasitology, 139(10), 1253-1265 (2012-06-22)
Leishmaniasis is a set of clinically distinct infectious diseases caused by Leishmania, a genus of flagellated protozoan parasites, that affects ~12 million people worldwide, with ~2 million new infections annually. Plants are known to produce substances to defend themselves against
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