T3019
α-Bungarotoxin from Bungarus multicinctus (Formosan Banded Krait)
solid
Synonym(s):
α-BuTX
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About This Item
MDL number:
UNSPSC Code:
12352200
form
solid
mol wt
~8 kDa
color
white
storage temp.
−20°C
Biochem/physiol Actions
Neurotoxin which binds irreversibly to motor endplate of acetylcholine receptors; prevents opening of nicotinic receptor-associated ion channels.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J Court et al.
Journal of neurochemistry, 73(4), 1590-1597 (1999-09-29)
Neuronal nicotinic receptors have been implicated in schizophrenia on the basis of the high incidence of tobacco smoking in patients, abnormalities in cytisine and alpha-bungarotoxin (alphaBGT) binding in the hippocampus, and linkage between auditory P50 deficits and the region of
M Akaaboune et al.
Science (New York, N.Y.), 286(5439), 503-507 (1999-10-16)
Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a half-life of about 14 days. However, 2 hours after neurotransmission
Masaki Hiramoto et al.
Developmental neurobiology, 69(14), 959-971 (2009-10-09)
The integration of multisensory information takes place in the optic tectum where visual and auditory/mechanosensory inputs converge and regulate motor outputs. The circuits that integrate multisensory information are poorly understood. In an effort to identify the basic components of a
James C Liao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(48), 12982-12992 (2008-11-28)
The neuronal networks in spinal cord can produce a diverse array of motor behaviors. In aquatic vertebrates such as fishes and tadpoles, these include escape behaviors, swimming across a range of speeds, and struggling. We addressed the question of whether
M Tanowitz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9426-9435 (1999-10-26)
Synapse-specific expression of the nicotinic acetylcholine receptor (AChR) is believed to be mediated by neuregulin, an epidermal growth factor-like trophic factor released by somatic motoneurons at the neuromuscular junction (NMJ). Neuregulin stimulates ErbB2, ErbB3, and ErbB4, members of the ErbB
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