T3019
α-Bungarotoxin from Bungarus multicinctus (Formosan Banded Krait)
solid
Synonym(s):
α-BuTX
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About This Item
UNSPSC Code:
12352200
MDL number:
form
solid
mol wt
~8 kDa
color
white
storage temp.
−20°C
Biochem/physiol Actions
Neurotoxin which binds irreversibly to motor endplate of acetylcholine receptors; prevents opening of nicotinic receptor-associated ion channels.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Product Information Sheet
J Court et al.
Journal of neurochemistry, 73(4), 1590-1597 (1999-09-29)
Neuronal nicotinic receptors have been implicated in schizophrenia on the basis of the high incidence of tobacco smoking in patients, abnormalities in cytisine and alpha-bungarotoxin (alphaBGT) binding in the hippocampus, and linkage between auditory P50 deficits and the region of
M Akaaboune et al.
Science (New York, N.Y.), 286(5439), 503-507 (1999-10-16)
Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a half-life of about 14 days. However, 2 hours after neurotransmission
M Tanowitz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9426-9435 (1999-10-26)
Synapse-specific expression of the nicotinic acetylcholine receptor (AChR) is believed to be mediated by neuregulin, an epidermal growth factor-like trophic factor released by somatic motoneurons at the neuromuscular junction (NMJ). Neuregulin stimulates ErbB2, ErbB3, and ErbB4, members of the ErbB