T3452
Toloxatone
≥98% (HPLC), solid
Synonym(s):
5-(Hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone, Humoryl
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About This Item
Empirical Formula (Hill Notation):
C11H13NO3
CAS Number:
Molecular Weight:
207.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
249-522-2
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cccc(c1)N2CC(CO)OC2=O
InChI
1S/C11H13NO3/c1-8-3-2-4-9(5-8)12-6-10(7-13)15-11(12)14/h2-5,10,13H,6-7H2,1H3
InChI key
MXUNKHLAEDCYJL-UHFFFAOYSA-N
Biochem/physiol Actions
Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant.
Toloxatone is a reversible monoamine oxidase A inhibitor (MAOI) and antidepressant. Toloxatone belongs to the aryloxazolidinones, a relatively new class of reversible monoamine oxidase A inhibitors (MAOI). Studies show that derivatives such as 3-aryloxazolidin-2-one (oxazolidinones), which are regularly used to treat gram positive infections, represent a new class of reversible as well as irreversible inhibitors for MAO-A and MAO-B enzymes that are able to inhibit protein synthesis and also used for neurodegenerative-type pathologies.
Preparation Note
Toloxatone is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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