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Merck
CN

T3830

Triciribine hydrate

≥97% (HPLC)

Synonym(s):

API-2, Akt/PKB Signaling Inhibitor-2, Inhibitor V, NSC 154020, TCN, VD-0002

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About This Item

Empirical Formula (Hill Notation):
C13H16N6O4 · xH2O
CAS Number:
35943-35-2
Molecular Weight:
320.30 (anhydrous basis)
MDL number:
MFCD16879015
UNSPSC Code:
12352200
PubChem Substance ID:
329826778
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥97% (HPLC)

form

powder

color

tan

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24

InChI

1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1

InChI key

SPGRLWCWHWRPHX-DOKXERMVSA-N

Gene Information

human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)

Related Categories

Application

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.

Biochem/physiol Actions

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Triciribine hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000467944
0000467944
0000239716
0000239716
0000131932

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Tsubasa Furuhashi et al.
Physiology & behavior, 168, 20-23 (2016-11-05)
Autonomic nervous system (ANS) imbalances are involved in the etiology of cancer, allergy, and collagen diseases. Previously, we hypothesized that FoxO and HSF-1 limit autonomic stress responses via negative feedback on the ANS. Here, we evaluated the role of AKT
Muhammad Miftahussurur et al.
PloS one, 11(12), e0166199-e0166199 (2016-12-03)
Information regarding Helicobacter pylori antibiotic resistance in Indonesia was previously inadequate. We assessed antibiotic susceptibility for H. pylori in Indonesia, and determined the association between virulence genes or genetic mutations and antibiotic resistance. We recruited 849 dyspeptic patients who underwent
Jérémie Neasta et al.
Biological psychiatry, 70(6), 575-582 (2011-05-10)
Neuroadaptations within the nucleus accumbens (NAc) have been implicated in molecular mechanisms underlying the development and/or maintenance of alcohol abuse disorders. We recently reported that the activation of mammalian target of rapamycin complex 1 (mTORC1) signaling pathway in the NAc
Hiroaki Kamijo et al.
The Journal of investigative dermatology, 140(3), 636-644 (2019-08-30)
Whereas atopic dermatitis (AD) is considered as a T helper 2 (Th2)-centered disease, IL-17-producing Th (Th17) cells are also activated in AD lesional skin. However, the relationship between Th17 responses and Th2 responses in AD is still to be elucidated.
Rocío López de la Lama et al.
PloS one, 13(8), e0202971-e0202971 (2018-08-30)
Misconceptions, lack of knowledge, and negative attitudes towards sharks act as barriers preventing actions required to tackle threats to shark populations, limiting the success of global shark conservation initiatives. Peru, a major player for the international trade of shark products
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