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T3932

Tyrphostin AG 1295

≥98%

Synonym(s):

6,7-Dimethyl-2-phenylquinoxaline

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About This Item

Empirical Formula (Hill Notation):
C16H14N2
CAS Number:
71897-07-9
Molecular Weight:
234.30
UNSPSC Code:
12352200
PubChem Substance ID:
24900180
MDL number:
MFCD00270912
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assay

≥98%

solubility

0.1 M HCl: soluble <1 mg/mL, ethanol: soluble 10 mg/mL, methylene chloride: soluble 10 mg/mL, 0.1 M NaOH: insoluble, 2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

storage temp.

−20°C

SMILES string

Cc1cc2ncc(nc2cc1C)-c3ccccc3

Gene Information

human ... EGFR(1956), FLT3(2322), PDGFRB(5159), SRC(6714)
mouse ... Pdgfrb(18596)

Application

Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.

Biochem/physiol Actions

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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