T4193
TNP-ATP hydrate
≥90% (HPLC), powder
Synonym(s):
2′,3′-O-(2,4,6-Trinitrophenyl) adenosine 5′-triphosphate monolithium trisodium salt
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About This Item
Empirical Formula (Hill Notation):
C16H13N8O19P3LiNa3 · xH2O
Molecular Weight:
790.15 (anhydrous basis)
UNSPSC Code:
12352200
SMILES string
[Li+].O.[Na+].[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)CP([O-])(=O)CP([O-])([O-])=O)[C@H]4OC5(O[C@@H]34)C(CC(CC5[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
assay
≥90% (HPLC)
form
powder
color
red to orange
solubility
H2O: <5 mg/mL, PBS: soluble
shipped in
dry ice
storage temp.
−70°C
Application
TNP-ATP has been used to inhibit P2X4 in rat microglial cells2. It has also been used as a P2X receptor antagonist in mice3.
Biochem/physiol Actions
TNP-ATP hydrate is a purinoceptor P2X2/3 antagonist.
Preparation Note
TNP-ATP hydrate is soluble in water at a concentration that is less than or equal to 5 mg/ml. It is also soluble in PBS3.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M F Jarvis et al.
British journal of pharmacology, 132(1), 259-269 (2001-01-13)
1. Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The predominant localization of P2X(3) mRNA in sensory neurones has led to the hypothesis
Fan Li et al.
BMC neuroscience, 12, 111-111 (2011-11-08)
Activation of amoeboid microglial cells (AMC) and its related inflammatory response have been linked to the periventricular white matter damage after hypoxia in neonatal brain. Hypoxia increases free ATP in the brain and then induces various effects through ATP receptors.
Koji Atarashi et al.
Nature, 455(7214), 808-812 (2008-08-22)
Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we
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