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T4509

4-Thiouridine

Name: 4-Thiouridine
Brand: SIGMA

≥98%, synthetic (organic), powder

Synonym(s):

4sU, RNA synthesis inhibitor, Thiouridine

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₂N₂O₅S

CAS Number:

13957-31-8

Molecular Weight:

260.27

NACRES:

NA.51

PubChem Substance ID:

24900212

UNSPSC Code:

41106305

EC Number:

237-735-3

MDL number:

MFCD00006538

Assay:

≥98%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 20 mg/mL, clear

Storage temp.:

−20°C

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Properties

Product Name

4-Thiouridine, ≥98%

biological source

synthetic (organic)

Quality Level

200

assay

≥98%

form

powder

solubility

water: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O

InChI

1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1

InChI key

ZLOIGESWDJYCTF-XVFCMESISA-N

Description

General description

4-Thiouridine is a photoreactive uridine analog.

Application

4-Thiouridine has been used in labeling and isolation of nascent RNAs.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.

Indira Memet et al.

Nucleic acids research, 45(9), 5359-5374 (2017-01-25)

In eukaryotes, the synthesis of ribosomal subunits, which involves the maturation of the ribosomal (r)RNAs and assembly of ribosomal proteins, requires the co-ordinated action of a plethora of ribosome biogenesis factors. Many of these cofactors remain to be characterized in

Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases.

Tsutomu Suzuki et al.

Annual review of genetics, 45, 299-329 (2011-09-14)

Mitochondria are eukaryotic organelles that generate most of the energy in the cell by oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a closed circular double-stranded DNA genome (mtDNA). Human (mammalian) mtDNA encodes 13 essential subunits of the inner

Genome-wide technology for determining RNA stability in mammalian cells: historical perspective and recent advantages based on modified nucleotide labeling.

Hidenori Tani et al.

RNA biology, 9(10), 1233-1238 (2012-10-05)

Changing the abundance of transcripts by regulated RNA degradation is a critical step in the control of various biological pathways. Recently, genome-wide inhibitor-free technologies for determining RNA stabilities in mammalian cells have been developed. In these methods, endogenous RNAs are

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Global Trade Item Number

SKU	GTIN
T4509-25MG	04061837346200
T4509-250MG	04061837346194
T4509-100MG	04061837346156