T4509
4-Thiouridine
≥98%, synthetic (organic), powder
Synonym(s):
4sU, RNA synthesis inhibitor, Thiouridine
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About This Item
Empirical Formula (Hill Notation):
C9H12N2O5S
CAS Number:
Molecular Weight:
260.27
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Product Name
4-Thiouridine, ≥98%
biological source
synthetic (organic)
Quality Level
Assay
≥98%
form
powder
solubility
water: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=S)NC2=O
InChI
1S/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)/t4-,6-,7-,8-/m1/s1
InChI key
ZLOIGESWDJYCTF-XVFCMESISA-N
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General description
4-Thiouridine is a photoreactive uridine analog.
Application
4-Thiouridine has been used in labeling and isolation of nascent RNAs.
Biochem/physiol Actions
4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tsutomu Suzuki et al.
Annual review of genetics, 45, 299-329 (2011-09-14)
Mitochondria are eukaryotic organelles that generate most of the energy in the cell by oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a closed circular double-stranded DNA genome (mtDNA). Human (mammalian) mtDNA encodes 13 essential subunits of the inner
Indira Memet et al.
Nucleic acids research, 45(9), 5359-5374 (2017-01-25)
In eukaryotes, the synthesis of ribosomal subunits, which involves the maturation of the ribosomal (r)RNAs and assembly of ribosomal proteins, requires the co-ordinated action of a plethora of ribosome biogenesis factors. Many of these cofactors remain to be characterized in
Lukas Windhager et al.
Genome research, 22(10), 2031-2042 (2012-04-28)
RNA synthesis and decay rates determine the steady-state levels of cellular RNAs. Metabolic tagging of newly transcribed RNA by 4-thiouridine (4sU) can reveal the relative contributions of RNA synthesis and decay rates. The kinetics of RNA processing, however, had so
Saskia Gressel et al.
Nature communications, 10(1), 3603-3603 (2019-08-11)
Eukaryotic gene transcription is often controlled at the level of RNA polymerase II (Pol II) pausing in the promoter-proximal region. Pausing Pol II limits the frequency of transcription initiation ('pause-initiation limit'), predicting that the pause duration must be decreased for
Gert-Jan Hendriks et al.
Nature communications, 10(1), 3138-3138 (2019-07-19)
Sequencing of newly synthesised RNA can monitor transcriptional dynamics with great sensitivity and high temporal resolution, but is currently restricted to populations of cells. Here, we develop new transcriptome alkylation-dependent single-cell RNA sequencing (NASC-seq), to monitor newly synthesised and pre-existing
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