T4952
Tanshinone IIA
≥97% (HPLC)
Synonym(s):
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione, Dan Shen ketone
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About This Item
Empirical Formula (Hill Notation):
C19H18O3
CAS Number:
Molecular Weight:
294.34
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352212
MDL number:
Quality Segment
assay
≥97% (HPLC)
form
powder
color
orange to dark red
solubility
methanol: 5 mg/mL, clear, red-orange to red
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
InChI
1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI key
HYXITZLLTYIPOF-UHFFFAOYSA-N
General description
Tanshinone IIA (Tan IIA) is a natural diterpene quinone, a lipophilic component derived from the root extract of Salvia miltiorrhiza.
Application
Tanshinone IIA has been used:
- to test its effect on osteoclast differentiation in ovariectomy-induced osteoporosis mouse modelPMID 29887959
- to test its effects on microglia and to study its neuroprotective effect on ischemia-reperfusion injured rat brainPMID 33953677
- to study its effects on the proliferation, apoptosis, and autophagy of acute myeloid leukemia (AML) in vitro and in vivo modelsPMID 31217869
- to investigate its anti-inflammatory and protective effects on ATDC5 cells from lipopolysaccharide (LPS)-induced inflammatory injuryPMID 29679904
Biochem/physiol Actions
Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.
Tanshinone IIA provides protective effects against cardiovascular diseases by enhancing angiogenesis. It elicits neuroprotective, anti-cancer, anti-diabetic, and anti-obesity properties. Tan-IIA plays a significant role in modulating the development and function of immune cells.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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