T5077
Tissue Factor Proteinase Inhibitor-II
recombinant, expressed in Nicotiana (tobacco), ≥97% (SDS-PAGE)
Synonym(s):
TFPI-2
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About This Item
Empirical Formula (Hill Notation):
C407H592N116O117S6
Molecular Weight:
9174.15
NACRES:
NA.77
UNSPSC Code:
12352204
recombinant
expressed in Nicotiana (tobacco)
assay
≥97% (SDS-PAGE)
form
solid
mol wt
~_9.2 kDa
storage temp.
−20°C
General description
First Kunitz domain of TFPI-II containing a lysine residue at position 24
Biochem/physiol Actions
Protease inhibitor of metastasis and angiogenesis
Protease inhibitor of metastasis and angiogenesis. Hypermethylation of the TFPI-2 gene causes transcriptional silencing in choriocarconoma cells. The TFPI-2 gene may be a candidate tumor suppressor gene.
Preparation Note
Soluble in water (0.5mg/ml) and in aqueous buffers of low ionic strength
Analysis Note
One mg will inhibit ≥1.3 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein.
Other Notes
One trypsin unit will produce a ΔA253 of 0.001 per min with BAEE as substrate at pH 7.6 at 25 °C; reaction volume 3.2 ml, 1 cm light path.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
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Florent Hubé et al.
Biological chemistry, 384(7), 1029-1034 (2003-09-06)
Tissue factor pathway inhibitor-2 (TFPI-2), a Kunitz-type serine proteinase inhibitor associated with the extracellular matrix, has been shown to reduce tumor invasion. In the present study we identified the presence of a complete CpG island region spanning exon 1 and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T5077-1MG | 04061826704141 |