T5567
Monoclonal Anti-TCF-1 (T-Cell Factor-1) antibody produced in mouse
~1 mg/mL, clone 7H3, purified immunoglobulin, buffered aqueous glycerol solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7H3, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen 26-48 kDa (32, 38, 42)
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, western blot: 0.5-2 μg/mL using whole extracts of Jurkat cells
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... HNF1A(6927)
Immunogen
MBP fusion protein corresponding to amino acids 109-269 of human TCF-1A splice variant.
Physical form
Solution in 0.1 M tris-glycine, pH 7.4, containing 0.15 M sodium chloride, 30% glycerol and 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Regulatory Information
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K Mayer et al.
International journal of cancer, 72(4), 625-630 (1997-08-07)
Physical interaction between the lymphoid high mobility group (HMG)-box architectural transcription factors TCF/LEF and beta-catenin is associated with translocation of the heteromeric complex to the nucleus and regulation of target gene expression. Since formation of molecular complexes among beta-catenin, E-cadherin
J Castrop et al.
Blood, 86(8), 3050-3059 (1995-10-15)
The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers. TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and
F J Staal et al.
International immunology, 11(3), 317-323 (1999-04-30)
Beta-catenin is the vertebrate homolog of the Drosophila segment polarity gene Armadillo and plays roles in both cell-cell adhesion and transduction of the Wnt signaling cascade. Recently, members of the Lef/Tcf transcription factor family have been identified as protein partners
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