T5818
Tyrphostin AG 974
≥98%, solid
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About This Item
Empirical Formula (Hill Notation):
C10H5IN2O2
CAS Number:
Molecular Weight:
312.06
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
assay
≥98%
form
solid
color
orange-brown
solubility
DMSO or ethanol: soluble
storage temp.
−20°C
Biochem/physiol Actions
Tyrphostin AG 974 is an EGFR protein tyrosine kinase inhibitor. Studies have reported that AG-974 can induce cell death in fibrosarcoma cell lines1.
Preparation Note
Tyrphostin AG 974 is soluble in DMSO or ethanol.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Sarit Bendetz-Nezer et al.
Molecular pharmacology, 66(3), 627-634 (2004-08-24)
DNA topoisomerases (topo) are the cellular targets of several anticancer drugs used today in the clinic. Our previous work demonstrated that certain tyrphostin derivatives, known as protein tyrosine kinase antagonists, are catalytic inhibitors of DNA topoisomerases I (topo I) in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T5818-5MG | 04061832276953 |
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