T5943
Tyrphostin AG 1007
≥98%, solid
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About This Item
Empirical Formula (Hill Notation):
C17H14N2O2S
CAS Number:
Molecular Weight:
310.37
NACRES:
NA.77
MDL number:
UNSPSC Code:
51112000
assay
≥98%
form
solid
color
yellow to green
solubility
DMSO: soluble, acetone: soluble
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Tyrphostin AG 1007 is known to function as a receptor tyrosine kinase inhibitor. It has been reported that replacement of oxygen in the carbonyl group of AG-1007 significantly increased the inhibition of tyrosine autophosphorylation of IGF-1R1.
Preparation Note
Tyrphostin AG 1007 is soluble in DMSO and acetone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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G Blum et al.
Biochemistry, 39(51), 15705-15712 (2000-12-22)
IGF-1 and its receptor play a pivotal role in many cancers, and therefore, IGF-1R is an attractive target for the design of inhibitors. In this communication, we report on a number of lead compounds for inhibitors of the isolated IGF-1R
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