T6259
DL-4-Thiaisoleucine
~98% (TLC)
Synonym(s):
2-Amino-3-(methylthio)butyric acid
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About This Item
Empirical Formula (Hill Notation):
C5H11NO2S
CAS Number:
Molecular Weight:
149.21
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
Product Name
DL-4-Thiaisoleucine,
Assay
~98% (TLC)
form
powder
color
white
storage temp.
−20°C
SMILES string
CSC(C)C(N)C(O)=O
InChI
1S/C5H11NO2S/c1-3(9-2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)
InChI key
PWDYHRMBGRYCAP-UHFFFAOYSA-N
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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M Green
The Journal of biological chemistry, 257(15), 9039-9042 (1982-08-10)
The incorporation of the leucine analog, beta-hydroxyleucine, or the isoleucine analog, 4-thiaisoleucine, into the MPOC-46B kappa chain interfered with the processing of the oligosaccharide moiety of newly synthesized light chains. Analog-containing chains were secreted with endo-beta-N-acetylglucosaminidase H-sensitive oligosaccharides instead of
Ian J Clifton et al.
Chembiochem : a European journal of chemical biology, 12(12), 1881-1885 (2011-06-17)
Isopenicillin N synthase (IPNS) catalyses the synthesis of isopenicillin N (IPN), the biosynthetic precursor to penicillin and cephalosporin antibiotics. IPNS is a non-heme iron(II) oxidase that mediates the oxidative cyclisation of the tripeptide δ-L-α-aminoadipoyl-L-cysteinyl-D-valine (ACV) to IPN with a concomitant
Eva S Istvan et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1627-1632 (2011-01-06)
Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine, which is not present in adult human hemoglobin and must be obtained exogenously. We evaluated two compounds for their
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