T6330
THI
sphingosine-1-phosphate lyase inhibitor, powder
Synonym(s):
2-ATHBI, 2-Acetyl-4-tetrahydroxybutyl Imidazole; 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
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About This Item
Empirical Formula (Hill Notation):
C9H14N2O5
CAS Number:
Molecular Weight:
230.22
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Product Name
THI,
form
powder
Quality Segment
color
white to light brown
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
InChI key
CQSIXFHVGKMLGQ-BWZBUEFSSA-N
Biochem/physiol Actions
2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.
THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant.
THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.
Preparation Note
THI is soluble in DMSO at a concentration that is greater than 5 mg/ml.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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