T6638
Tolnaftate
Synonym(s):
Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
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About This Item
Empirical Formula (Hill Notation):
C19H17NOS
CAS Number:
Molecular Weight:
307.41
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51302004
EC Number:
219-266-6
MDL number:
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
chloroform: soluble 50 mg/mL
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3
InChI
1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
InChI key
FUSNMLFNXJSCDI-UHFFFAOYSA-N
Application
Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.
Biochem/physiol Actions
Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.
Packaging
1G,5G
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Product Information Sheet
Andrew E Czeizel et al.
Reproductive toxicology (Elmsford, N.Y.), 18(3), 443-444 (2004-04-15)
Teratogenic studies of tolnaftate, an antifungal agent, in humans have not been published. The population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996 contained 22843 fetuses or newborns with congenital abnormalities and 38151 matched controls without congenital
J Pannu et al.
Antimicrobial agents and chemotherapy, 53(8), 3273-3279 (2009-05-13)
NB-002 is an oil-in-water emulsion designed for use for the treatment of skin, hair, and nail infections. The activity of NB-002 was compared to the activities of the available antifungal drugs against the major dermatophytes responsible for cutaneous infections, Trichophyton
H Vanden Bossche et al.
Journal of veterinary pharmacology and therapeutics, 26(1), 5-29 (2003-02-27)
A limited number of antifungal agents is licensed for use in animals, however, many of those available for the treatment of mycoses in humans are used by veterinary practitioners. This review includes chemical aspects, spectra of activity, mechanisms of action
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T6638-1G | 04061837371790 |
| T6638-5G | 04061837371806 |