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T6764

Triprolidine hydrochloride

≥99%, H1 histamine receptor antagonist

Synonym(s):

(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H22N2 · HCl
CAS Number:
6138-79-0
Molecular Weight:
314.85
UNSPSC Code:
12352200
PubChem Substance ID:
24277808
NACRES:
NA.77
MDL number:
MFCD00039044
Assay:
≥99%
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Product Name

Triprolidine hydrochloride, ≥99%

Quality Segment

assay

≥99%

solubility

alcohol: soluble 1 in 1.5 of solvent, chloroform: soluble 1 in less than 1 of solvent, H2O: soluble 50 mg/mL, clear, colorless to yellow

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl

InChI

1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;

InChI key

WYUYEJNGHIOFOC-NWBUNABESA-N

Gene Information

human ... HRH1(3269)

Application

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons.

Biochem/physiol Actions

H1 histamine receptor antagonist.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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