T6779
Tolmetin sodium salt dihydrate
Synonym(s):
1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium salt dihydrate
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About This Item
Linear Formula:
C15H14NO3Na · 2H2O
CAS Number:
Molecular Weight:
315.30
UNSPSC Code:
12161501
PubChem Substance ID:
EC Number:
252-687-3
MDL number:
solubility
H2O: soluble 50 mg/mL, clear, colorless
SMILES string
[Na+].[H]O[H].[H]O[H].Cc1ccc(cc1)C(=O)c2ccc(CC([O-])=O)n2C
InChI
1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1
InChI key
QQILXENAYPUNEA-UHFFFAOYSA-M
Application
An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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R Scott Obach
Drug metabolism and disposition: the biological fate of chemicals, 37(8), 1581-1586 (2009-05-15)
During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as
Mitra Jelvehgari et al.
Pharmaceutical development and technology, 15(1), 71-79 (2009-06-10)
Ethylcellulose microparticles containing tolmetin sodium, an anti-inflammatory drug, were prepared by a solvent diffusion method based on the formation of multiple W/O(1)/O(2)-emulsion. The drug used was TOL, which is water-soluble and n-hexane was used as the non-solvent. Important parameters in
David R Ely et al.
International journal of pharmaceutics, 414(1-2), 157-160 (2011-05-24)
In this work, near infrared (NIR) hyperspectral imaging was used to quantify the spatial distribution of drug in tablets containing tolmetin sodium dihydrate. Hyperspectral data cubes were generated by imaging the same spatial region of a sample while illuminated by
Antonio Tito et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 72(5), 1000-1006 (2009-02-03)
The formation of tolmetin/N-acetyl-l-tyrosine ethyl ester (ATEE) complex has been reported by means of both theoretical and experimental studies, including quantum mechanical calculations as well as UV-vis absorption, fluorescence and time-resolved spectroscopy measurements. It has been found that the fluorescence
Embedded-polar-group bonded phases for high performance liquid chromatography.
O'Gara, J. E., et al.
LC-GC, 19(6), 632-642 (2001)
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