T7290
Tyrphostin 25
≥98%
Synonym(s):
(3,4,5-Trihydroxybenzylidene)malononitrile
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About This Item
Empirical Formula (Hill Notation):
C10H6N2O3
CAS Number:
Molecular Weight:
202.17
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Oc1cc(cc(O)c1O)\C=C(\C#N)C#N
assay
≥98%
potency
3 μM IC50
solubility
DMSO: >50 mg/mL, clear, yellow to orange
storage temp.
2-8°C
Gene Information
human ... EGFR(1956)
Application
Tyrphostin 25 has been used for studying its effect on transcriptional repression induced by the adenoviral oncoprotein, E1a, in HeLa cells. Tyrphostin 25 has also been used to study the migration inhibition in IEC-6 cells.
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 25 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Preparation Note
Tyrphostin 25 is soluble in DMSO at a concentration that is greater than 50 mg/ml and yields a clear, yellow to orange solution.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J Lechner et al.
Renal failure, 23(3-4), 573-588 (2001-08-14)
The therapeutic administration of Interferon alpha2b (IFNalpha) is often accompanied by impaired renal function, i.e. reduced glomerular filtration rate and sometimes a so-called "capillary leak syndrome". To clarify the mechanism behind the renal dysfunction, confluent monolayers of LLC-PK1 cells were
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In this study, we investigated the ability of prostaglandin F(2alpha) (PGF(2alpha)) to induce tyrosine phosphorylation of phospholipase C-gamma1 (PLC-gamma1) in cat iris sphincter smooth muscle (CISM) cells. PGF(2alpha)(1 microM) stimulated PLC-gamma1 tyrosine phosphorylation in a time- and dose-dependent manner with
Mahaboobi Jaleel et al.
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Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues. The receptor has an extracellular domain, a single transmembrane spanning domain, and an intracellular domain that harbors a
Lian Hua Fang et al.
FEBS letters, 512(1-3), 282-286 (2002-02-20)
This study was undertaken to determine the role of tyrosine kinase on intracellular Ca(2+) ([Ca(2+)](i)), myosin light chain (MLC) phosphorylation, and contraction caused by norepinephrine (NE) in rat aorta. NE induced a sustained contraction with an increase of [Ca(2+)](i). On
Maria Grazia Zizzo et al.
European journal of pharmacology, 521(1-3), 133-138 (2005-09-28)
The aim of this study was to investigate the signal transduction mechanisms underlying the inhibitory effect induced by pituitary adenylate cyclase activating peptide (PACAP-27) on the spontaneous contractile activity of longitudinal muscle of mouse ileum. Mechanical activity of ileal segments
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