T7290
Tyrphostin 25
≥98%
Synonym(s):
(3,4,5-Trihydroxybenzylidene)malononitrile
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About This Item
Empirical Formula (Hill Notation):
C10H6N2O3
CAS Number:
Molecular Weight:
202.17
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98%
potency
3 μM IC50
solubility
DMSO: >50 mg/mL, clear, yellow to orange
storage temp.
2-8°C
SMILES string
Oc1cc(cc(O)c1O)\C=C(\C#N)C#N
Gene Information
human ... EGFR(1956)
Application
Tyrphostin 25 has been used for studying its effect on transcriptional repression induced by the adenoviral oncoprotein, E1a, in HeLa cells. Tyrphostin 25 has also been used to study the migration inhibition in IEC-6 cells.
Biochem/physiol Actions
EGFR tyrosine kinase inhibitor.
Tyrphostin 25 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
Preparation Note
Tyrphostin 25 is soluble in DMSO at a concentration that is greater than 50 mg/ml and yields a clear, yellow to orange solution.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Lian Hua Fang et al.
FEBS letters, 512(1-3), 282-286 (2002-02-20)
This study was undertaken to determine the role of tyrosine kinase on intracellular Ca(2+) ([Ca(2+)](i)), myosin light chain (MLC) phosphorylation, and contraction caused by norepinephrine (NE) in rat aorta. NE induced a sustained contraction with an increase of [Ca(2+)](i). On
Debjani Ghosh et al.
Bioscience reports, 22(3-4), 395-406 (2003-01-09)
In this study we show that protein tyrosine kinases (PTKs) and also protein tyrosine phosphatases are involved in the uptake of virulent and avirulent Leishmania donovani promastigotes by macrophage cells. Protein tyrosine kinase inhibitors such as genistein or tyrphostin 25
Maria Grazia Zizzo et al.
European journal of pharmacology, 521(1-3), 133-138 (2005-09-28)
The aim of this study was to investigate the signal transduction mechanisms underlying the inhibitory effect induced by pituitary adenylate cyclase activating peptide (PACAP-27) on the spontaneous contractile activity of longitudinal muscle of mouse ileum. Mechanical activity of ileal segments
Yu-Jing Gao et al.
Cardiovascular research, 71(2), 363-373 (2006-06-08)
Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS). In Wistar-Kyoto rats, rings of
Israel Rubinstein
Journal of applied physiology (Bethesda, Md. : 1985), 103(1), 184-189 (2007-04-14)
The purpose of this study was to determine whether protein tyrosine kinase, a ubiquitous family of intracellular signaling enzymes that regulates endothelial cell function, modulates bradykinin- and substance P-induced increase in macromolecular efflux from the intact hamster cheek pouch microcirculation.
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