T7444
Anti-phospho-Tau (pSer404) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable, western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer404)
Quality Level
Gene Information
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
General description
Tau is a microtubule-associated phosphoprotein that is present in the axons of nerve cells. It stabilizes microtubules and mediates the polymerization of tubulin. Phosphorylation of Tau regulates its cellular functions. Hyperphosphorylation of Tau has been linked to neurodegenerative disorders such as Alzheimer′s disease . Anti-phospho-Tau (pSer404) antibody specifically reacts with Tau (pSer404) (45-68 kDa) in humans, mice and rats.
Immunogen
chemically synthesized phosphopeptide derived from the region of human tau that contains serine404.
Application
Anti-phospho-Tau (pSer404) antibody may be used in western blot (1:1000), immunoblot (1:1000) and immunohistochemistry.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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N Haque et al.
Brain research, 838(1-2), 69-77 (1999-08-14)
Tau, one of the best characterized microtubule-associated proteins (MAPs), is a phosphoprotein, the biological activity of which is regulated by its degree of phosphorylation. The objective of the present study was to evaluate the regulation, phosphorylation and the biological activity
Océane Guillemaud et al.
Neurobiology of aging, 90, 135-146 (2020-03-17)
In Alzheimer disease (AD), astrocytes undergo complex changes and become reactive. The consequences of this reaction are still unclear. To evaluate the net impact of reactive astrocytes in AD, we developed viral vectors targeting astrocytes that either activate or inhibit
S M Jenkins et al.
The Biochemical journal, 345 Pt 2, 263-270 (2000-01-06)
Tau is a microtubule-associated protein that is functionally modulated by phosphorylation and hyperphosphorylated in several neurodegenerative diseases. Because phosphorylation regulates both normal and pathological tau functioning, it is of great interest to identify the signalling pathways and enzymes capable of
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